The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
-Huang J, et al. 2012 Nature.

• "...menin contains a deep pocket that binds short peptides of MLL1 or JUND in the same manner, but... can have opposite effects on transcription.
• "The menin–JUND interaction blocks JUN N-terminal kinase (JNK)-mediated JUND phosphorylation and suppresses JUND-induced transcription."
• "In contrast, menin promotes gene transcription by binding the transcription activator MLL1 through the peptide pocket..."