Long-Term Natural Course of Pituitary Tumors in Patients With MEN1

Long-Term Natural Course of Pituitary Tumors in Patients With MEN1: Results From the DutchMEN1 Study Group (DMSG)

Joanne M. de Laat, Olaf M. Dekkers, et al.
The Journal of Clinical Endocrinology & Metabolism 2015 100:9, 3288-3296;

Results:

...Ninety-one percent of the nonfunctioning PIT detected during screening (n = 35), did not require intervention during followup (median, 6.0 y). Three microadenomas showed limited growth but did not progress toward macroadenomas. Both screening-detected and prevalent prolactinomas ...responded well to treatment with dopamine agonists.

Conclusion:

Systematic presymptomatic screening for PIT in patients with MEN1 predominantly results in detection of nonfunctioning microadenomas. Prolactinoma in patients with MEN1 responded well to medical treatment. Microadenomas grew only occasionally and after many years without clinical consequences. Frequent magnetic resonance imaging followup of nonfunctioning microadenomas in the context of MEN1 and sporadically occurring PITs therefore seems debatable.

MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas

MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas
-G Walls, M Lemos, et al.
Journal of Cancer Research, OnlineFirst August 21, 2012; doi: 10.1158/0008-5472.CAN-12-1821

• "In this study, we conducted a preclinical evaluation of MEN1 gene therapy in pituitary tumors of Men1+/- mice, using a recombinant non-replicating adenoviral serotype 5 vector..."
  
• "Menin expression was higher in the Men1.rAd5-treated mice when compared to other groups. Daily proliferation rates assessed by BrdU incorporation were reduced significantly in Men1.rAd5-injected tumors relative to control treated tumors."
  
• "Our findings establish that MEN1 gene replacement therapy can generate menin expression in pituitary tumors, and significantly reduce tumor cell proliferation."
  

The Genetics of Pituitary Adenomas

The Genetics of Pituitary Adenomas
-Monica Fedele, Giovanna Maria Pierantoni and Alfredo Fusco (2011). The Genetics of Pituitary Adenomas, Contemporary Aspects of Endocrinology, Dr. Evanthia Diamanti-Kandarakis (Ed.), ISBN: 978-953-307-357-6, InTech, Available from: http://www.intechopen.com/books/contemporary-aspects-of-endocrinology/the-genetics-of-pituitary-adenomas

Endoscopic endonasal transsphenoidal surgery for functional pituitary adenomas

Endoscopic endonasal transsphenoidal surgery for functional pituitary adenomas
-Hofstetter C, et al. Neurosurg Focus 30 (4):E10, 2011

• Description of endoscopic endonasal transsphenoidal surgery.
• Results from the resection of 86 functional pituitary adenomas at Weill Cornell Medical College, New York–Presbyterian Hospital, from 2004-2010.