Prolactin Receptor in Primary Hyperparathyroidism – Expression, Functionality and Clinical Correlations

Prolactin Receptor in Primary Hyperparathyroidism – Expression, Functionality and Clinical Correlations
-Haglund F, et al. PLoS ONE May 2012, Volume 7, Issue 5, e36448.

• "...the prolactin receptor is highly abundant in human parathyroid tissues"
• "...PRLr isoforms expression and PRLr subcellular localisation are altered in parathyroid tumours."
• "Responsiveness of PRLr to physiological levels of prolactin was observed in the form of increased PTH secretion and altered gene transcription with significant increase of RIG-I like receptor, JAK-STAT and Type II interferon signalling pathways."
• "These data suggest a role of the prolactin receptor in parathyroid adenomas."