Female patients with MEN1 are at increased risk for breast cancer

Breast-Cancer Predisposition in Multiple Endocrine Neoplasia Type 1

K. Dreijerink, P. Goudet, et al.
New England Journal of Medicine
N Engl J Med 2014; 371:583-584; August 7, 2014; DOI: 10.1056/NEJMc1406028

Notes:

• Intensified breast-cancer screening at a relatively young age should be considered in female patients with MEN1.
  

Prolactin produced in the breast may play a role in breast cancer

http://www.medicalnewstoday.com/releases/250906.php

• "...prolactin has long been thought to play a role in human breast cancer, however this has typically been assumed to be due to circulating prolactin produced by the pituitary. Since the PI3K-Akt signaling pathway is commonly activated in human cancers, this new finding suggests the important possibility that prolactin produced by the breast itself may play a role in breast cancer."
  
• "Since the PI3K-Akt pathway is one of the most commonly activated oncogenic pathways in human cancer, its identification as an upstream regulator of prolactin production in the mammary gland has intriguing potential implications for understanding the pathology of human breast cancer and as well as improving its treatment..."
  

-Medical News Today, October 2, 2012