Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation

Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation
-Dreijerink KM, et al. Nat Clin Pract Endocrinol Metab. 2006 Oct;2(10):562-70.

• "Menin maintains transforming growth factor beta mediated signal transduction involved in parathyroid hormone and prolactin gene expression;"
• "We propose that menin links transcription-factor function to histone-modification pathways and that this is crucial for MEN1 tumorigenesis."