Research shows how medicine for the brain can be absorbed through the nose
-University of Southern Denmark. "Research shows how medicine for the brain can be absorbed through the nose." Medical News Today. MediLexicon, Intl., 27 Sep. 2013. Web. 27 Sep. 2013.
Editor's notes:
There may be a wonderful use for nasal administration in the treatment of medically resistant pituitary prolactinomas. These are commonly treated medically by oral administration of the dopamine agonists cabergoline (CAB) or bromocriptine (BRO). But in some patients normalization of PRL (prolactin) levels is not achieved with even unusually high doses of CAB or BRO. If CAB or BRO can be delivered effectively to the brain via nasal administration, it may be possible to produce higher therapeutic levels of the drug at the pituitary tumor while avoiding the undesired increased exposure to other systems which may be affected: such as the kidneys, pancreas, and immune system.
Cref: Dopamine -Wikipedia
Showing posts with label editor's notes. Show all posts
Showing posts with label editor's notes. Show all posts
September 27, 2013
June 11, 2013
Menin -today's growth promoter, tomorrow's tumor suppressor
Elucidating the Role of Menin During Islet Cell Development in the Human Fetal Pancreas
-Dubrick, Jessica L., (2013).
University of Western Ontario - Electronic Thesis and Dissertation Repository. Paper 1287.
http://ir.lib.uwo.ca/etd/1287
editor's notes:
Menin functions as a tumor suppressor in adult endocrine cells, but in the fetal pancreas promotes cell survival and proliferation. At first glance these roles seem very different, almost opposite. But are they really opposed?
If menin promotes the proliferation of healthy pancreas cells -in particular, cells with at least one functional MEN1 gene- then it would seem that these cells will proliferate faster than those unable to produce menin. So, cells that are unable to produce menin will represent a decreasing fraction of the cell population. Therefore, even during fetal development, menin's role as a growth promoter offers a tumor suppressive advantage to the developing pancreas, by reducing the percentage of cells that later may pose a tumorigenic risk due to their inability to express menin.
Unless I've got that wrong.
-Dubrick, Jessica L., (2013).
University of Western Ontario - Electronic Thesis and Dissertation Repository. Paper 1287.
http://ir.lib.uwo.ca/etd/1287
editor's notes:
Menin functions as a tumor suppressor in adult endocrine cells, but in the fetal pancreas promotes cell survival and proliferation. At first glance these roles seem very different, almost opposite. But are they really opposed?
If menin promotes the proliferation of healthy pancreas cells -in particular, cells with at least one functional MEN1 gene- then it would seem that these cells will proliferate faster than those unable to produce menin. So, cells that are unable to produce menin will represent a decreasing fraction of the cell population. Therefore, even during fetal development, menin's role as a growth promoter offers a tumor suppressive advantage to the developing pancreas, by reducing the percentage of cells that later may pose a tumorigenic risk due to their inability to express menin.
Unless I've got that wrong.
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