Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation

Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation
-Dreijerink KM, et al. Nat Clin Pract Endocrinol Metab. 2006 Oct;2(10):562-70.

• "Menin maintains transforming growth factor beta mediated signal transduction involved in parathyroid hormone and prolactin gene expression;"
• "We propose that menin links transcription-factor function to histone-modification pathways and that this is crucial for MEN1 tumorigenesis."

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
-Huang J, et al. 2012 Nature.

• "...menin contains a deep pocket that binds short peptides of MLL1 or JUND in the same manner, but... can have opposite effects on transcription.
• "The menin–JUND interaction blocks JUN N-terminal kinase (JNK)-mediated JUND phosphorylation and suppresses JUND-induced transcription."
• "In contrast, menin promotes gene transcription by binding the transcription activator MLL1 through the peptide pocket..."