- Menin is important for the writing of histone H3K4 trimethylation.
- In MEN1 tumors, writing of H3K4me3 on specific target genes is blocked.
- Compounds that interfere with the removal of the histone methylation mark are being developed.
- Specific targeting of menin-HMT to treat tumors poses a great challenge for future research.
May 29, 2012
Multiple endocrine neoplasia type 1: a chromatin writer’s block
Multiple endocrine neoplasia type 1: a chromatin writer’s block
-Dreijerink, K. M. A., Lips, C. J. M. and Timmers, H. T. M. (2009). Journal of Internal Medicine, 266: 53–59. doi: 10.1111/j.1365-2796.2009.02115.x
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment