Direct Binding of DNA by Tumor Suppressor Menin

Direct Binding of DNA by Tumor Suppressor Menin
-Ping La, et al. Journal of Biological Chemistry, Vol. 279, No. 47. Nov. 2004.

• "Menin directly binds to double-stranded DNA."
• "The COOH terminus of menin mediates binding to DNA, but MEN1 disease-derived mutations in the COOH terminus abolish the ability of menin to bind DNA."
• "MEN1 disease-related menin mutants also fail to repress cell proliferation as well as cell cycle progression at the G2/M phase."
• "Collectively, these results demonstrate... a novel biochemical activity of menin, binding to DNA, and link its DNA binding to the regulation of cell proliferation."