February 2, 2015

Prolactin Receptor in Primary Hyperparathyroidism

PLOS ONE: Prolactin Receptor in Primary Hyperparathyroidism – Expression, Functionality and Clinical Correlations


We demonstrate that the prolactin receptor is highly abundant in human parathyroid tissues and that PRLr isoforms expression and PRLr subcellular localisation are altered in parathyroid tumours. Responsiveness of PRLr to physiological levels of prolactin was observed in the form of increased PTH secretion and altered gene transcription with significant increase of RIG-I like receptor, JAK-STAT and Type II interferon signalling pathways. These data suggest a role of the prolactin receptor in parathyroid adenomas.