Hyperprolactinemia or pseudohyperprolactinemia?

Reporting of Post–PEG Prolactin Concentrations: Time to Change
-T Smith, M Fahie-Wilson
Clinical Chemistry March 2010 vol. 56 no. 3 484-485

Measurement of serum prolactin levels can be exagerated by the presence of biologically inactive "big prolactin" or "macroprolactin", aka "big big prolactin".

"The polyethylene glycol (PEG) precipitation test is widely used to detect pseudohyperprolactinemia caused by big prolactin and/or macroprolactin. Current best practice recommends that all sera with increased total prolactin concentrations be subfractionated by PEG precipitation to measure the bioactive monomeric prolactin concentration, a more clinically meaningful variable."

MEN1 -overview and treatment

Multiple endocrine neoplasia type 1 (MEN1)
-Richard W. Carroll
Asia-Pacific Journal of Clinical Oncology,Wiley Online Library, 2012
doi: 10.1111/ajco.12046

DCA (dichloroacetic acid) - a possible future cancer treatment?

Dichloroacetic acid - Wikipedia, the free encyclopedia

There are wild rumors that DCA (dichloroacetic acid) "cures" cancer. Ignoring what seem to be premature and extreme claims, the facts about DCA are interesting to consider. Perhaps DCA may have a future in cancer treatment.

Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2

Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2

-C. Romei, et al.
Journal of Oncology, Volume 2012, Article ID 705036

MEN1 intragenic deletions appear common in sporadic primary hyperparathyroidism

MEN1 intragenic deletions may represent the most prevalent somatic event in sporadic primary hyperparathyroidism

-M Alvelos, et al.
European Journal of Endocrinology, October 23, 2012 EJE-12-0327

MEN Syndrome and M.E.N. 1: Parathyroid, Pituitary, Pancreas, Thyroid Tumors and MEN type 1 Syndrome - Disorders of the Parathyroid, Pituitary, and Pancreas

MEN Syndrome and M.E.N. 1: Parathyroid, Pituitary, Pancreas, Thyroid Tumors and MEN type 1 Syndrome - Disorders of the Parathyroid, Pituitary, and Pancreas

An overview of MEN1, its treatment, and what patients can expect.

By James Norman MD, FACS, FACE
Norman Parathyroid Center
http://www.parathyroid.com/Parathyroid-Surgeon.htm

Prolactin produced in the breast may play a role in breast cancer

http://www.medicalnewstoday.com/releases/250906.php

• "...prolactin has long been thought to play a role in human breast cancer, however this has typically been assumed to be due to circulating prolactin produced by the pituitary. Since the PI3K-Akt signaling pathway is commonly activated in human cancers, this new finding suggests the important possibility that prolactin produced by the breast itself may play a role in breast cancer."
  
• "Since the PI3K-Akt pathway is one of the most commonly activated oncogenic pathways in human cancer, its identification as an upstream regulator of prolactin production in the mammary gland has intriguing potential implications for understanding the pathology of human breast cancer and as well as improving its treatment..."
  

-Medical News Today, October 2, 2012