Reporting of Post–PEG Prolactin Concentrations: Time to Change
-T Smith, M Fahie-Wilson
Clinical Chemistry March 2010 vol. 56 no. 3 484-485
Measurement of serum prolactin levels can be exagerated by the presence of biologically inactive "big prolactin" or "macroprolactin", aka "big big prolactin".
"The polyethylene glycol (PEG) precipitation test is widely used to detect pseudohyperprolactinemia caused by big prolactin and/or macroprolactin. Current best practice recommends that all sera with increased total prolactin concentrations be subfractionated by PEG precipitation to measure the bioactive monomeric prolactin concentration, a more clinically meaningful variable."
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