February 28, 2012

The amino acid sequence of menin

The human gene MEN1 (also the name of the disorder associated with a mutant MEN1 gene) encodes the protein menin. UniProt specifies three isoforms of menin, Isoform 1 being called the 'canonical' sequence.1 It is 615 amino acids in length, the others being 610 and 575 amino acids in length, respectively.

Menin Isoform 1:
10 20 30 40 50 60 MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE 70 80 90 100 110 120 LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 130 140 150 160 170 180 VSDVIWNSLS RSYFKDRAHI QSLFSFITGW SPVGTKLDSS GVAFAVVGAC QALGLRDVHL 190 200 210 220 230 240 ALSEDHAWVV FGPNGEQTAE VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME 250 260 270 280 290 300 VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR 310 320 330 340 350 360 PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR 370 380 390 400 410 420 EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ GTQSQGSALQ DPECFAHLLR 430 440 450 460 470 480 FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEEPWGEEA 490 500 510 520 530 540 REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP RKPPGTVAGT ARGPEGGSTA 550 560 570 580 590 600 QVPAPTASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP 610 SDYTLSFLKR QRKGL
The table contains standardized single-letter codes for the various amino acids. Wikipedia offers a table describing these codes.2
For example, the "Q" at amino acid position 64 represents glutamine, which is encoded either by codons CAA or CAG.3
__________
1 UniProt entry on "MEN1_HUMAN"
2 http://en.wikipedia.org/wiki/Amino_acid#Table_of_standard_amino_acid_abbreviations_and_properties (Wikipedia: Amino Acid).
3 http://en.wikipedia.org/wiki/Genetic_code#RNA_codon_table (Wikipedia: Genetic Code).

No comments:

Post a Comment