January 28, 2012

Chemical marks on histones

Chemical 'marks' that can be written upon histones include:
  • acetylation
  • methylation
  • ubiquitination
  • phosphorylation
The possible combinations of histone marks are nearly unlimited, and are referred to as the 'histone code'.
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Multiple endocrine neoplasia type 1: a chromatin writer’s block. Dreijerink, K. M. A., Lips, C. J. M. and Timmers, H. T. M. (2009). Journal of Internal Medicine, 266: 53–59. doi: 10.1111/j.1365-2796.2009.02115.x
Acetylation and Methylation of Histones and Their Possible Role in the Regulation of RNA Synthesis. Allfrey VG, et al. Proc Natl Acad Sci USA. 1964 May; 51(5): 786–794. PMCID: PMC300163.
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1 comment:

  1. John F RobinFebruary 8, 2012 at 9:22 PM

    Perhaps a correction is called for. The Allfrey paper of 1964 described methylation as a chemical mark upon histones. According to newer sources (11, and Wikipedia), methylation takes place on CpG sequences of the DNA itself.

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