December 12, 2014

Ghrelin receptor alters dopamine signaling

Appetite accomplice: Ghrelin receptor alters dopamine signaling -- ScienceDaily

  • Dopamine signaling in the hypothalamus is linked with feeding behavior, and mutations in DRD2 that attenuate dopamine signaling are associated with obesity in humans.
  • When mice were treated with a molecule (cabergoline) that selectively activates DRD2, they exhibited anorexia.